Dapovar™ was specifically designed to address the three (3) principle factors that contribute to a lack of ejaculatory control in sexually active men.

The Effects of Serotonin on Male Orgasm Control

There is definitive medical and scientific evidence that increasing serotonin levels relative to other neurotransmitters improves ejaculatory control in men. There are over [172] supporting articles referenced by The National Library Of Medicine (PubMED), published in the medical literature that demonstrate that increasing serotonin centrally or the use of certain prescription antidepressants of the serotonin-selective type (SSRI's) are useful in delaying early or premature ejaculation and improve climax control.

To accomplish an increase in central serotonin levels in a natural non-prescription manner, Dapovar™ contains L-5-Hydroxytryptophan (L-5-HTP), the immediate natural building block (precursor) of serotonin from a concentrated and standardized botanical source. L-5-HTP is only one (1) natural biosynthetic step away from forming the neurotransmitter serotonin.

To help insure the consistent and maximal conversion of L-5-HTP to serotonin, specific enzymatic co-factors (vitamins/micronutrients) are required for the efficient formation of serotonin. These necessary co-factors are included in the patented formulation Dapovar™. The added enzymatic co-factors are: pyridoxine (Vitamin B-6), pyridoxal-5-phosphate (active form of Vitamin B-6), and folic acid (folate).

The importance of these enzymatic co-factors: The 1989 Borden Award Lecture defined certain effects of dietary components on brain serotonin synthesis, mood, and behavior. In part of this study, a vitamin B-6 deficiency was deliberately induced in rats. It was discovered that very little serotonin was produced in the rat brain when deficient in B-6. In other experiments, the presence of ample amounts of B-6 - even to the point of "moderate excess" - increased production of serotonin (centrally) from 5-HTP by up to 60%. Pyridoxine deficiency causes a physiologically significant decrease in brain serotonin (5-HT) due to decreased decarboxylation of 5-hydroxytryptophan (5-HTP).
Concerning folic acid, as early as 1982, Harvard Medical School researchers reported in Compounds Nutrition and Depression: The Role of Folate that a folic acid deficiency could cause low brain serotonin levels. Many recent studies indicate that low folate levels are linked to poorer antidepressant response to serotonin selective re-uptake inhibitors (SSRI's) because of a decreased brain synthesis of serotonin.

The Effects of Dopamine and Testosterone on Orgasm Control

There is definitive medical and scientific evidence referenced by The National Library Of Medicine (PubMed) [111 articles], that elevated levels of dopamine can have a profound negative impact on ejaculatory control in men and show that drugs which stimulate dopamine receptors can actually cause premature ejaculation. As early as 1972, it was reported in Life Science Journal "that dopamine is the central mediator of emission of seminal fluid in male rats". Furthermore, there are over [492 articles] published in the medical literature that links elevated dopamine neurotransmission with aggravating existing premature ejaculation or even causing early ejaculation in men who otherwise had no difficulties with maintaining ejaculatory control.

A very common and natural cause of elevated dopamine levels is the normally high levels of testosterone found in youthful males (18-40 year old males). Reference Laboratories on Endocrine Measurements generally state "Free testosterone levels in adult males ranges from 52-280 picograms/ml, with the average being 138 picograms/ml". There is considerable correlation between testosterone levels and dopamine levels, [492 articles] referenced by the National Library of Medicine. As a result, elevated testosterone levels tend to result in elevated dopamine levels and consequently youthful males generally report greater difficulty with ejaculatory control.

Dapovar™ has been specially formulated to temporarily minimize the negative influence of elevated dopamine in men without having any effect on natural testosterone levels. Pyridoxine (vitamin B-6) and pyridoxal 5-phosphate (active form of vitamin B-6) serve dual roles in the patented Dapovar™ formulation because they help to minimize unwanted dopamine influence (by accelerating dopamine metabolism/breakdown) while also optimizing the conversion of L-5-HTP to serotonin.

The Effects of Anxiety on Lack of Orgasm Control

Anxiety can often be an important factor or contributor to lack of ejaculatory control in men and these effects are well-documented in the medical literature. There are over 100 supporting articles, referenced by The National Library Of Medicine (PubMED), published in the medical literature, that demonstrate anxiety and early ejaculation are causally-linked. Dapovar™ has been scientifically formulated to effectively address the unwanted performance anxiety often associated with sex.
3.A) A principle pathway of reliable and efficient conversion of L-5HTP to serotonin is one way Deferol� helps to combat unwanted performance anxiety. Serotonin itself has calmative, mood regulating, and anti-anxiety effects.

3.B) The other principle pathway Dapovar™ achieves its effect involves the inclusion of a naturally-occuring bioflavinoid that is found in Passiflora coerulea extract, also known as 5,7-dihydroxyflavone or chrysin. This plant (Passiflora coerulea) is used in natural medicine to reduce anxiety. Chrysin appears to exert its anti-anxiety effects through the benzodiazepine receptor. Several animal studies suggest that chrysin possesses anxiolytic actions without inducing sedation and muscle relaxation. These studies suggest that this natural flavinoid is a partial agonist of the central benzodiazepine receptors, but unlike diazepam (Valium®) or other benzodiazepines, it has no effect on sedation, muscle-relaxing or memory tasks.

It is a fairly widespread practice among "body-builders" to take very large doses of chrysin to maximize the androgenic (male hormone) effects of testosterone precursors (such as DHEA, androstenedione, androstenediol, and their derivatives, etc.) or anabolic steroids. However, Dapovar™ contains only a small amount of chrysin - just enough to help reduce anxiety levels, but not enough to increase natural testosterone levels.

In summary, the scientific rationale of the Dapovar™ was based on the synergistic scientific effects of its natural dietary ingredients which, in this Patent Pending combination, help to promote greater climax control and enable